The ByWater Institute is a nationally recognized environmental research institute focused on solutions science that addresses the grand challenges facing the ecosystems, communities and businesses along coastlines and rivers of the US. Using the Mississippi River Basin as our testbed, ByWater's growing number of experts and partners will advance a new scholarly approach to solutions science called “clinical trials for planetary health” — diagnosing problems and producing, testing and communicating solutions at unprecedented speeds and scales. ByWater’s overriding goal: Help create cities, coastlines and river basins in the region and beyond that are Thriving ByWater in an era of increasing climate extremes.