Oak Ridge National Laboratory is the largest science and energy national laboratory in the Department of Energy system. ORNL’s scientific programs focus on materials, neutron science, energy, high-performance computing, systems biology and national security. ORNL partners with the state of Tennessee, universities and industries to solve challenges in energy, advanced materials,manufacturing, security and physics. The laboratory's science and technology innovations are translated into applications for economic development and global security. The laboratory is home to several of the world’s top supercomputers and is a leading neutron science and nuclear energy research facility that includes the Spallation Neutron Source and High Flux Isotope Reactor. ORNL hosts a DOE Leadership Computing Facility—home of the Titan supercomputer; one of DOE’s nanoscience centers—the Center for Nanophase Materials Sciences; the BioEnergy Science Center—one of DOE’s Energy Research Centers; and the Consortium for Advanced Simulation of Light-Water Reactors, a DOE Innovation Hub.