A research opportunity is available at the U.S. Environmental Protection Agency’s (EPA) Office of Land and Emergency Management (OLEM) Office of Superfund Remediation and Technology Innovation (OSRTI), Assessment and Remediation Division (ARD)
Perfluorinated alkyls (PFAS) are a growing concern for EPA. Human health risk assessments depend on accurate estimates of exposure and as clear an understanding as possible of what exposure levels may be harmful. Reference doses (RfD) based on oral intake exist for some PFAS. However little is currently known about the toxicokinetics of inhaled PFAS. We do not know, for example, what duration and concentration of inhaled PFAS corresponds to concentrations in serum following oral exposure. Answering this question will help EPA and others estimate total serum concentrations (from oral intake and inhalation) rather than relying on information from oral intake data alone. The goal of this project is to build a physiological model that estimates the amount of inhaled PFAS that reaches the blood stream.
Through this project, the participant will have the opportunity to: expand their understanding of how inhaled chemicals move through the body and partition to different physiological compartments. It will also provide an opportunity for the participant to learn about route-to-route extrapolations, modeling, human health and chemical risk assessments and learn about the functions and roles of EPA scientists.